Table 2.
Clonal profile for point mutations in GBM genes. All mutations in GBM driver genes (including intronic) are presented.
| Gene | Sample ID | Tissue | Formal Clone Status | Cell Fraction | Functional Impact |
|---|---|---|---|---|---|
| NLRP5 | 3724T | Tumor | Subclonal | 0.18 | Medium |
| DRD5 | 3427T | Tumor | Subclonal | 0.22 | None |
| DRD5 | 7015 | PDCL | Clonal | 0.83 | None |
| DRD5 | 7015 | PDCL | Subclonal | 0.73 | None |
| DRD5 | 7015 | PDCL | Subclonal | 0.27 | None |
| ABCC9 | 7142 | PDCL | Clonal | 1 | None |
| DRD5 | 7015 | PDCL | Subclonal | 0.73; 0.27 | None |
| LZTR1 | 7015 | PDCL | Clonal | 1 | None |
| PIK3R1 | N13-1520 | PDCL | Clonal | 1 | None |
| RB1 | 7015 | PDCL | Subclonal | 0.38 | Medium |
| SPTA1 | 7097 | PDCL | Clonal | 1 | Medium |
| TCHH | 7015 | PDCL | Subclonal | 0.21 | High |
| TCHH | 7015 | PDCL | Subclonal | 0.24 | Low |
| TP53 | 7015 | PDCL | Clonal | 1 | High |
| TP53 | N13-1520 | PDCL | – | 1 | High |
| ATRX | 3719T-7015 | Both | Clonal → clonal | 1 → 1 | High |
| EGFR | 3427T-6240 | Both | – | 1 → 1 | Medium |
| EGFR | 3722T-7060 | Both | Clonal → clonal | 1 → 1 | Low |
| GABRA6 | 4724T-N13-1520 | Both | – | 0.91 → 1 | Low |
| KEL | 3719T-7015 | Both | Clonal → subclonal | 1 → 0.64 | High |
| NF1 | 3719T-7014 | Both | – | 1 → 1 | High |
| NF1 | 4724T-N13-1520 | Both | – | 0.68 → 1 | Medium |
| PIK3CA | 3427T-6240 | Both | Clonal → subclonal | 1 → 0.82 | None |
| PIK3CA | 3719T-7014 | Both | – | 1 → 1 | Medium |
| PTEN | 3523T-7097 | Both | Clonal → clonal | 1 →1 | High |
| PTEN | 3724T-7142 | Both | – | 1 →1 | High |
| SPTA1 | 3427T-6240 | Both | – | 0.94 →0.84 | Medium |