Skip to main content
. 2017 Jan 25;11(3):254–260. doi: 10.1080/19336950.2017.1284717

Figure 1.

Figure 1.

Acute application of cisplatin and blasticidin does not affect currents mediated by 8A-VFP/8E-mCh or 8A-VFP/8D-mCh. (A) Typical current traces of 8A-VFP/8E-mCh expressing oocytes evoked by the “IV-pulse protocol” (see Materials and Methods) in control conditions and after perfusion of 1 mM cisplatin (top) or 0.25 mM blasticidin (bottom). (B) 8A-VFP/8E-mCh currents measured at 60 mV in presence of 1mM cisplatin or 0.25 mM blasticidin were normalized to the value measured before drug application (n = 5 for cisplatin; n = 3 for blasticidin). (C-D) Acute effect of cisplatin and blasticidin on 8A-VFP/8D-mCh. (C) Voltage clamp traces of oocytes expressing 8A-VFP/8D-mCh before and after perfusion of 1 mM cisplatin (top) or 0.25 mM blasticidin (bottom). (D) 8A-VFP/8D-mCh currents recorded at 60 mV were normalized to the value measured before drug application (n = 3). Error bars indicate SD.