Table 1.
Characterisitcs of arginase, nitric oxide-related clinical parameters
| Variables | Total | Male | Female | p | Age <46 | Age ≥47 | p | |||
|---|---|---|---|---|---|---|---|---|---|---|
| (n = 184) | (n = 120) | (n = 64) | (n = 92) | (n = 92) | ||||||
| Age | 46.3 ± 1.0 | 45.3 ± 1.3 | 48.0 ± 1.6 | 0.225 | 34.5 ± 0.9 | 58 ± 0.6 | <0.0001 | |||
| Sex (M/F) | 120/64 | 63/29 | 57/35 | 0.353 | ||||||
| BMI | 23.6 ± 0.3 | 23.9 ± 0.3 | 22.9 ± 0.4 | 0.034 | 23.4 ± 0.4 | 23.7 ± 0.4 | 0.576 | |||
| Arginase I | 5.2 ± 0.3 | 5.8 ± 0.3 | 4.0 ± 0.4 | <0.0001 | 5.4 ± 0.4 | 5.0 ± 0.4 | 0.292 | |||
| Arginase activity | 4.3 ± 0.2 | 4.9 ± 0.2 | 3.2 ± 0.3 | <0.0001 | 4.5 ± 0.3 | 4.2 ± 0.3 | 0.323 | |||
| l-Arginine | 197.7 ± 3.5 | 206.7 ± 4.3 | 181.1 ± 5.4 | 0.0005 | 195.3 ± 4.7 | 200.2 ± 5.2 | 0.604 | |||
| l-Citrulline | 315.6 ± 9.0 | 322.7 ± 10.6 | 301.8 ± 16.6 | 0.372 | 317.5 ± 11.6 | 313.7 ± 13.9 | 0.956 | |||
| l-Ornithine | 345.0 ± 10.1 | 359.8 ± 13.4 | 316 ± 13.2 | 0.047 | 324.7 ± 11.2 | 366.4 ± 16.6 | 0.024 | |||
| l-Citru + l-Orni | 614.4 ± 16.2 | 638.3 ± 20.3 | 578 ± 25.0 | 0.037 | 607.4 ± 20.5 | 628.2 ± 24.5 | 0.631 | |||
| l-Arg/l-Citru + l-Orni | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.31 ± 0.1 | 0.677 | 0.30 ± 0.1 | 0.30 ± 0.1 | 0.203 | |||
| l-Arg/l-Citru | 0.70 ± 0.1 | 0.68 ± 0.1 | 0.70 ± 0.1 | 0.280 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.570 | |||
| l-Citru/l-Orni | 1.0 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 0.085 | 1.0 ± 0.1 | 0.9 ± 0.1 | 0.073 | |||
| l-Arg/l-Orni | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.637 | 0.60 ± 0.1 | 0.60 ± 0.1 | 0.027 | |||
| NOx | 33.3 ± 1.6 | 34.9 ± 2.2 | 30.4 ± 2.0 | 0.113 | 29.6 ± 1.4 | 37.10 ± 2.8 | 0.024 | |||
| FeNO | 20.7 ± 1.4 | 21.70 ± 1.9 | 18.7 ± 2.0 | 0.059 | 22.5 ± 2.5 | 18.90 ± 1.3 | 0.934 | |||
| FVE1% | 88.6 ± 0.6 | 88.8 ± 0.8 | 88.4 ± 1.1 | 0.906 | 91.8 ± 0.8 | 85.50 ± 0.9 | <0.0001 | |||
| Systolic blood pressure | 125.0 ± 1.1 | 126.2 ± 1.3 | 122.6 ± 2.2 | 0.136 | 120.3 ± 1.4 | 129.7 ± 1.7 | <0.0001 | |||
| Diastolic blood pressure | 78.2 ± 0.8 | 79.9 ± 1.0 | 74.9 ± 1.4 | 0.0027 | 75.5 ± 1.1 | 80.9 ± 1.1 | 0.0002 | |||
| hs-CRP | 0.9 ± 0.1 | 0.80 ± 0.1 | 1 ± 0.3 | 0.102 | 0.9 ± 0.2 | 0.80 ± 0.1 | 0.015 | |||
| HDL-c | 57.2 ± 1.2 | 53.9 ± 1.6 | 63.4 ± 1.6 | <0.0001 | 56.5 ± 2.0 | 57.90 ± 1.5 | 0.240 | |||
| IgE | 128.6 ± 12.6 | 138.5 ± 17.1 | 110.2 ± 16.9 | 0.109 | 151.2 ± 20.8 | 106.0 ± 14.0 | 0.065 | |||
| Exercise habit (+/–) | 62/122 | 50/70 | 12/52 | 0.024 | 32/60 | 30/62 | 0.756 | |||
| Smoking habit (+/–) | 72/112 | 60/60 | 12/52 | <0.0001 | 36/57 | 38/55 | 0.765 | |||
| Alcohol drinking (+/–) | 108/76 | 82/38 | 26/38 | 0.0003 | 52/40 | 56/36 | 0.549 |
Values represent mean ± SEM, and bold indicates statistical significance.