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. 2017 Jun 8;8:962. doi: 10.3389/fmicb.2017.00962

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Copyright © 2017 Liu, Guo, Liu, Zhang, Zeng, Ning and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Susceptibilities of S. mutans UA159 strains to different antimicrobials. (A) Growth of S. mutans UA159 and lmrB mutant in the presence of different concentration of chlorhexidine (CHX), penicillin, and erythromycin. An overall decreased sensitivity to all the three antimicrobials was observed. (B) Biofilm formation ability of S. mutans UA159 strains under 0.25xMIC of CHX pressure. No significant difference was observed in the lmrB mutant with and without 0.25xMIC of CHX (p > 0.05), while 0.25xMIC of CHX suppressed biofilm formation ability of S. mutans UA159 in the initial 12 h (p < 0.05). ^∗Significant difference compared with the untreated control (p < 0.05).