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. Author manuscript; available in PMC: 2017 Oct 13.
Published in final edited form as: Nat Chem Biol. 2017 Apr 13;13(5):455–463. doi: 10.1038/nchembio.2353

Figure 6. Conformational changes in the pore associated with slow inactivation.

Figure 6

a, An extracellular view of the pore through the selectivity filter. The selectivity filter collapses from a four-fold symmetric shape in pre-open NaVAb (left) to an oval shape in inactivated NaVAb (middle) to a completely closed pore in inactivated NaVRh (right). b, An intracellular view of the pore at the C-termini of the S6 segments. The pore distorts from a square shape in the pre-open NaVAb structure to a parallelogram shape in the inactivated NaVAb and NaVRh structures.