Table 2.

Odds Ratio (95% Confidence Intervals) of Membership in Feature-Specific Schizotypy Classes

	Cognitive-Perceptual			Interpersonal			Disorganized
Predictor	Unadjusted	Adjusted	Fully Adjusted	Unadjusted	Adjusted	Fully Adjusted	Unadjusted	Adjusted	Fully Adjusted
Cannabis use	1.06 (0.85–1.32)	1.06 (0.84–1.34)	1.13 (0.88–1.44)	1.06 (0.88–1.27)	1.05 (0.87–1.28)	0.96 (0.75–1.24)	1.08 (0.93–1.25)	1.15 (0.98–1.35)	1.06 (0.88–1.29)
Pregnancy and obstetric	1.33 (0.91–1.95)	1.33 (0.91–1.95)	1.22 (0.78–1.92)	0.93 (0.60–1.46)	0.95 (0.60–1.49)	0.97 (0.62–1.53)	0.77 (0.50–1.19)	0.74 (0.48–1.35)	0.77 (0.49–1.21)
Family history	1.43 (0.36–5.64)	1.48 (0.37–5.83)	1.47 (0.34–6.43)	1.97 (0.70–5.53)	1.97 (0.70–5.54)	1.56 (0.45–5.42)	1.89 (0.78–4.58)	1.96 (0.78–4.92)	1.99 (0.74–5.34)
Poor social adjustment	3.36 (0.73–15.36)	3.64 (0.77–17.17)	3.94 (0.77–20.12)	14.60*** (4.01–53.15)	14.66*** (4.02–53.51)	13.05*** (3.37–50.90)	9.68*** (3.08–30.48)	13.55*** (3.98–46.17)	9.10** (2.41–34.36)
Genetic risk score	8.94 (0.59–134.95)	12.76 (0.84–194.69)	8.07 (0.43–150.30)	5.82 (0.58–57.92)	6.03 (0.60–60.48)	4.43 (0.32–60.94)	1.99 (0.33–12.18)	3.05 (0.47–19.68)	1.18 (0.14–10.29)
rs1625579	0.81 (0.36–1.84)	0.92 (0.40–2.12)	—	1.14 (0.53–2.44)	1.16 (0.54–2.47)	—	0.93 (0.52–1.67)	0.99 (0.55–1.78)	—
rs7004633	2.20* (1.11–4.38)	2.33* (1.15–4.72)	—	0.93 (0.47–1.84)	0.93 (0.46–1.87)	—	0.79 (0.45–1.40)	0.88 (0.49–1.57)	—
rs7914558	0.98 (0.45–2.10)	0.96 (0.45–2.08)	—	1.86 (0.92–3.75)	1.85 (0.91–3.76)	—	1.48 (0.89–2.47)	1.61 (0.93–2.77)	—
rs12966547	1.46 (0.72–2.95)	1.53 (0.74–3.18)	—	1.40 (0.78–2.51)	1.39 (0.77–2.49)	—	1.43 (0.89–2.27)	1.47 (0.91–2.39)	—

Note: Adjusted, sex and ethnicity included; fully adjusted, sex and ethnicity and both risk factors included; unadjusted, risk factor only. The fully adjusted models were run with the 5 original risk measures, and not individual SNPs.

*P < .05, **P < .01, ***P < .001.