Table 2.
Median PFS and OS by clinical, histopathologic, molecular and radiographic characteristics
| Characteristic (n) | Median PFS, y (95% CI) |
P | Median OS, y (95% CI) |
P |
|---|---|---|---|---|
| Age | .87 | .69 | ||
| <40 (61) | 3.8 (2.6–5.8) | 10.2 (7.3–11.8) | ||
| ≥40 (59) | 3.8 (2.7–5.3) | 9.2 (6.4–NA) | ||
| Performance status | .72 | .51 | ||
| KPS 90–100 (106) | 3.7 (2.8–4.9) | 10.8 (7.1–NA) | ||
| KPS < 90 (12) | 4.3 (2.7–6.3) | 9.2 (5.7–11.1) | ||
| Extent of resection | .003 | .01 | ||
| STR (92) | 4.3 (3.5–5.4) | 10.1 (7.1–NA) | ||
| Biopsy only (28) | 2.0 (1.3–5.2) | 7.2 (2.4–NA) | ||
| Histology | .08 | .007 | ||
| Oligodendroglioma (57) | 4.6 (3.8–5.7) | 10.8 (7.3–NA) | ||
| Astrocytoma (43) | 3.3 (1.1–NA) | 7.1 (5.0–NA) | ||
| Oligoastrocytoma (20) | 2.7 (1.8–5.0) | 5.7 (2.8–NA) | ||
| Molecular subgroup | .01 | <.001 | ||
| 1p/19q codel (44) | 4.9 (3.8–NA) | 9.7 (7.3–NA) | ||
| IDH1 mut (31) | 3.6 (2.1–5.4) | 11.2 (6.9–NA) | ||
| Wild type (13) | 0.6 (0.4–NA) | 1.8 (1.1–NA) | ||
| Pretreatment tumor volume | <.001 | <.001 | ||
| Volume ≤ 68cm3 (54) | 4.9 (4.2–7.6) | 11.2 (10.8–NA) | ||
| Volume > 68cm3 (17) | 1.7 (1.3–3.7) | 4.2 (2.4–NA) |
P-values are calculated using the Tarone–Ware test.