. 2016 Jan 15;193(2):223–224. doi: 10.1164/rccm.1932erratum

Table E5.

Sample-Size Estimates across Outcomes

Outcome	Control^* (%)	Intervention (%)	Absolute Risk Reduction (%)	Relative Risk Reduction (%)	N per Group	No. PICUs^† (1 yr)	No. PICUs^† (3 yr)
New or progressive MODS	40	35	5	13	1,471	245	81
New or progressive MODS	40	30	10	25	356	59	20
PICU mortality	24	19	5	21	1,059	177	58
PICU mortality	24	14	10	42	241	40	13
Hospital mortality	25	20	5	20	1,094	182	60
Hospital mortality	25	15	10	40	250	42	14
At least mild disability^‡	28	23	5	18	1,192	199	65
At least mild disability^‡	28	18	10	36	277	46	15
At least moderate disability^§	17	12	5	29	778	130	43
At least moderate disability^§	17	7	10	59	165	28	9
Death or disability^\|\|	38	33	5	13	1,437	240	79
Death or disability^\|\|	38	28	10	26	346	58	19

Definition of abbreviations: MODS = multiorgan dysfunction syndrome; PICU = pediatric intensive care unit.

Baseline estimate from SPROUT study.

^{^†}

Number of PICUs required to meet sample size is estimated based on a median of 16 beds per PICU and a median PICU length of stay of 15 days per patient with a 50% consent rate.

^{^‡}

Any increase in POPC from baseline to hospital discharge in the 422 hospital survivors.

^{^§}

Discharge POPC ≥ 3 and an increase of at least 1 from baseline in the 422 hospital survivors.

^{^||}

Death or at least moderate disability at hospital discharge.