Figure 4.

Rescue of mice from lethal vaccinia pneumonia by an ErbB inhibitor. (A) Mouse survival curves after i.n. vaccinia inoculation following pretreatment with CI-1033 (1 mg/mouse/day) and/or anti-L1R (200 μg i.p. 6 hours before inoculation). Note that all control mice died by day 7. Each treatment group includes a cohort of 5 animals. (B) Clinical score of mice during treatment. The score (0–4) is explained in Methods and is the mean value of the 5 mice per group. (C) Average weight of the entire lung 6 days after lethal vaccinia infection with or without indicated treatment (n = 3 per group) versus normal, uninfected lung. (D) Virus titers in lungs at day 8 after infection. Results are representative of 5 experiments.