Figure 5.

Postexposure therapy of VV infection in the C57BL/6 pneumonia model. Mice were inoculated i.n. with 2 × 10⁴ PFU of VV, and 2 days later were treated with a single dose of mAb L1R or control mAb and/or with CI-1033, the latter given daily until termination of the experiment. Mice were sacrificed on different days after infection and examined for lung weight (A), VV PFU/lung (B), and the number of anti-CD3–induced IFN-γ–producing CD8⁺ T cells per spleen (C). For days 6, 7, and 8, group sizes of 3–4, 5, or 6 animals, respectively, were employed. At day 8, 2 of 6 anti–L1R-treated mice had undetectable virus, whereas 5 of 6 anti-L1R plus CI-1033–treated mice had undetectable virus. For calculation of mean titers, the lowest detectable titer possible (1 log) was used for mice without detectable virus, such that the means are actually lower values. *P < 0.05.