Table 1.

Association of imaging parameters with survival based upon Cox proportional hazards analysis, adjusting for age, KPS, and extent of resection. Metrics with P< .05 were considered to be significant and the P values marked with an asterisk are those that are less than .0024, which would be the cutoff for a Bonferroni correction for 21 independent statistical tests (corresponding to 7 types of parameters and 3 time points).

Parameter	OS			PFS
	Pre-RT	Mid-RT	Post-RT	Pre-RT	Mid-RT	Post-RT
Anatomic volumes
# Patients	39	29	38	39	29	38
T2 lesion	ns	ns	.0012*	ns	ns	.0076
CE lesion	ns	ns	.0027	ns	ns	.0160
Metabolic volumes
# Patients	35	26	35	35	26	35
CNI >2	ns	.0150	<.0001*	ns	ns	.0390
CNI >2 and T2 lesion	ns	ns	.0021*	ns	ns	ns
Choline relative to NAA in the same voxel
# Patients	35	26	35	35	26	35
median(CNI)	.0077	.0099	ns	ns	.021	ns
maximum(CNI)	ns	.0008*	.0021*	ns	ns	ns
sum(CNI)	ns	.0028*	.0007*	ns	ns	ns
median(xsChoN)	.0010*	.0002*	.0006*	ns	.017	.0340
maximum xsChoN	.0180	.0002*	.0004*	ns	ns	ns
sum(xsChoN)	ns	.0041	.0007*	ns	ns	ns
Choline relative to creatine in the same voxel
# Patients	35	26	35	35	26	35
median(CCrI)	.0018*	.0046	ns	ns	.017	ns
maximum(CCrI)	.0230	.0018*	.0056	ns	ns	ns
sum(CCrI)	ns	.0031	.0008*	ns	ns	ns
median(xsChoCr)	.0001*	.0110	ns	ns	.028	ns
maximum(xsChoCr)	.0250	.0021*	.0120	ns	ns	ns
sum(xsChoCr)	ns	.0068	.0071	ns	ns	ns
Lactate, lipid relative to nNAA in normal appearing brain
# Patients	35	26	35	35	26	35
median(nLac)	ns	ns	ns	ns	ns	ns
maximum(nLac)	ns	.0450	ns	ns	ns	ns
sum(nLac)	ns	.0170	.0007*	ns	ns	ns
median(nLip)	ns	ns	ns	ns	ns	ns
maximum(nLip)	ns	ns	ns	ns	ns	ns
sum(nLip)	ns	.0096	.0191	.0241	ns	ns

ns = P value not significant.