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Canine glioma histology. (A) Anaplastic astrocytoma with pleomorphism, anisokaryosis, nuclear atypia, and mitotic activity. (B) GFAP staining of anaplastic astrocytoma. (C) High-grade oligodendroglioma composed of ovoid to fusiform cells and endothelial vascular proliferation. (D) Olig2 immunohistochemistry demonstrates strong nuclear positivity of more than 90% of neoplastic cells. Images courtesy of Dr Miller, Purdue Veterinary Medicine.
