Table 2.

MRI parameters in leptomeningeal disease

MRI prerequisites

1.5T and 3T MR scanners only

Use of same MRI at baseline and follow-up

MRI to be performed prior to lumbar puncture

Recommended MRI sequences

Brain

Volumetric 3D T1 (magnetization-prepared rapid acquisition with gradient echo [MPRAGE] or spoiled gradient [SPGR]) postcontrast image with isotropic 1-mm voxels to permit reformatting in 3 planes (axial, coronal, and sagittal)

Reformatted slice thickness 3 mm to obtain good signal to noise ration and manageable number of slices for full brain coverage

IV contrast dose = 0.1 mmol/kg of gadolinium-based agent.

Spine

Volumetric 3D T1 (MPRAGE or SPGR) postcontrast image in sagittal plane with isotropic 1 mm voxels to permit reformatting in 3 planes (axial, coronal, and sagittal) with a 2‒3 mm reformatted slice thickness without gap.