Fig. 2.

Binding of tropisetron. Predicted binding clusters for tropisetron docked into (A) a homology model of the 5-HT₃ receptor binding site based upon the template 2WNC (Model-1), and (B) the crystal structure 2YME (Model-2). (C) Co-crystal structures 2WNC and 2YME show AChBP bound with tropisetron and granisetron respectively. In panels 2A & 2B all 10 predicted ligand poses are overlaid. 5-HT₃ receptor residues within 5 Å of tropisetron in each of these poses are shown in Table 1.