Table 6.

Log‐normal sensitivity analysis ‐ the effects of pharmacokinetic parameters and partitioning coefficients on plasma EGCg concentration‐time profile

Pharmacokinetic parametersa	Sensitivity coefficients		Partitioning coefficientsa	Sensitivity coefficients
	Ratb	Humanc		Ratb	Humanc
BW	10.1	—	Rbn	—	—
BLPLR	–1.1	–1.1	Rbr	—	—
CLbc	—d	—	Rft	—	—
CLrc	—	–0.7	Rgt	—	—
F	29.4	15.2	Rhr	—	—
R t	—	—	Rkd	—	—
k ac	—	−4.8	Rlg	—	—
k fc	—	—	Rlv	—	—
k rac	—	—	Rms	—	1.9
tlag	—	0.8	Rrb	—	1.2
			Rsk	—	—
			Rsp	—	—

^aSee Tables 2, 3, 4, 5 and Appendix for explanation on parameter abbreviations.

^bRats are given a single oral dose of PE containing 2500 mg/kg crude EGCg (Zhu et al. 2000).

^cHumans are given a single oral dose of pure EGCg (5.33 mg/kg) (Chow et al. 2001).

^d– Represents less than 0.5 in absolute value.