Table 6.
Pharmacokinetic parametersa | Sensitivity coefficients | Partitioning coefficientsa | Sensitivity coefficients | ||
---|---|---|---|---|---|
Ratb | Humanc | Ratb | Humanc | ||
BW | 10.1 | — | Rbn | — | — |
BLPLR | –1.1 | –1.1 | Rbr | — | — |
CLbc | —d | — | Rft | — | — |
CLrc | — | –0.7 | Rgt | — | — |
F | 29.4 | 15.2 | Rhr | — | — |
R t | — | — | Rkd | — | — |
k ac | — | −4.8 | Rlg | — | — |
k fc | — | — | Rlv | — | — |
k rac | — | — | Rms | — | 1.9 |
tlag | — | 0.8 | Rrb | — | 1.2 |
Rsk | — | — | |||
Rsp | — | — |