Table 7.

Using C _max as a dose surrogate to predict plasma dosimetry of TCM in humans

GT solids and PE pharmacokinetic studies in humans	Predicted and actual C max in the plasma (μg/mL)			Total TCM concentration in the plasma (μg EGCg equivalents/mL)d	Administered TCM dose metrics (mg EGCg equivalents/kg)e
	EGCG	EGC	EC
Lee et al. (2002); 20 mg/kg GT solids	0.06a (0.08)b	0.07 (0.22)c	0.04 (0.12)c	0.20	6.06
Chow et al. (2005); 400 mg PE	0.11 (0.14)	0.01 (0.02)	0.01 (0.00)	0.13	8.42
Chow et al. (2001); 600 mg PE	0.21 (0.17)	0.02 (0.01)	0.01 (0.01)	0.21	12.46
Chow et al. (2005); 800 mg PE	0.21 (0.29)	0.02 (0.03)	0.01 (0.00)	0.25	15.71
Chow et al. (2005); 1200 mg PE	0.35 (0.92)c	0.04 (0.04)	0.02 (0.01)	0.42	26.70

^aValues without brackets are predicted C _max of unchanged TCs based on PBPK modeling.

^bBracketed values are C _max from the literature. These C _max usually are determined from free tea catechin concentrations except those of Lee et al. (2002) study, which are determined from total tea catechin concentrations (free plus conjugated forms).

^cC_max is under‐predicted when compare with the observed value.

^dTotal TCM concentrations are expressed as μg EGCg equivalents/mL plasma; they are calculated using predicted C _max and the concentration/dose additivity model (ATSDR, 2004).

^eAdministered dose metrics are expressed as mg EGCg equivalents/kg BW; they are calculated using the concentrations of individual TCs in PE and the additivity model (ATSDR, 2004).