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Assessment of pain efficacy in rat MIA model. Rats injected with MIA was treated with various doses of EP4 antagonists (compound 2 or CJ‐042,794) or the NSAID diclofenac (5 mg/kg) and pain was measured 1 h post dosing by an incapacitance test (materials and methods). The data are presented as mean ± SEM where group size n is 4 or 5. Statistical comparison to vehicle: Dunnett's test and between groups Tukey HSD (*/**/***P < 0.05).
