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Efficacy in adjuvant induced arthritis model of inflammation. Rats injected with adjuvant for 11 days were treated with various doses of EP4 antagonists (compound 2 or CJ‐023,423) diclofenac, or vehicle for 4 days and the paw width was determined before and after compound treatments. The data are expressed as % increase in paw swelling. The data are presented as mean ± SEM (n = 8). Statistical comparison to vehicle: Dunnett's test (*P < 0.05).
