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. 2017 May 14;5(3):e00316. doi: 10.1002/prp2.316

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© 2017 Eli Lilly. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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EP4 Antagonists in Collagen II induced arthritis model. Arthritis was induced in rats by intradermal injection of type II collagen as described (Materials and Methods). Treatment with indicated doses of EP4 antagonist (compound 3) or prednisone (10 mg/kg) started on day 11 post collagen injection. After 17 days of treatments, hind paws and knee joints were collected for histology, ankles and knees were assessed for histopathology. Panel A: Individual scores; Panel B: Total histopathological scores; Panel C: Periosteal Bone measure.