Table 5.
Blood biomarker data are shown as medians and interquartile ranges (in square brackets) and are compared with baseline levels. Significant changes are bolded
| Biomarker | Baseline | C1D2 | C1D8 | C1D10 | C2D1 |
|---|---|---|---|---|---|
| SDF_1a |
1727 [1463, 1967]
(N = 20) |
1668 [1518, 1828] (N = 19) |
1452 [1340, 1657]
(N = 17) |
1661 [1348, 1823] (N = 11) |
1479 [1398, 1691] (N = 13) |
| P value | NA | 0.47 | 0.008 | 0.07 | 0.06 |
| bFGF | 35 [25, 74] (N = 20) |
35 [23, 52] (N = 19) |
36 [20, 55] (N = 17) |
34 [14, 67] (N = 11) |
35 [23, 56] (N = 14) |
| P value | NA | 0.89 | 0.61 | 0.52 | 0.81 |
| PlGF | 26 [21, 38] (N = 20) |
26 [22, 41] (N = 19) |
19 [15, 20]
(N = 17) |
17 [12, 33]
(N = 11) |
17 [15, 25]
(N = 14) |
| P value | NA | 0.49 | 0.001 | 0.003 | 0.001 |
| sFLT_1 | 114 [84, 139] (N = 20) |
101 [73, 146] (N = 19) |
111 [86, 131] (N = 17) |
117 [97, 171] (N = 11) |
101 [80, 133] (N = 14) |
| P value | NA | 0.12 | 0.40 | 0.97 | 0.33 |
| VEGF | 156 [86, 272] (N = 20) |
119 [68, 286] (N = 19) |
119 [83, 141]
(N = 17) |
141 [66, 229] (N = 11) |
86 [70, 130]
(N = 14) |
| P value | NA | 0.26 | 0.04 | 0.08 | 0.02 |
| CAIX | 45 [26, 108] (N = 19) |
45 [30, 74] (N = 19) |
111 [49, 196]
(N = 17) |
144 [81, 206]
(N = 12) |
155 [75, 218]
(N = 13) |
| P value | NA | 1.00 | 0.005 | 0.005 | 0.001 |
| VEGFR2 | 9471 [7868, 10867] (N = 20) |
9476 [7894, 10480] (N = 19) |
8088 [6857, 10152] (N = 17) |
8008 [7276, 10852] (N = 12) |
7680 [7306, 9657]
(N = 13) |
| P value | NA | 0.80 | 0.07 | 0.30 | 0.03 |
| Ang_2 | 2328 [1806, 3219] (N = 20) |
2508 [1734, 3012] (N = 19) |
2810 [1975, 4145]
(N = 17) |
3241 [2640, 5554] (N = 12) |
2534 [2402, 3679] (N = 13) |
| P value | NA | 0.31 | 0.02 | 0.052 | 0.59 |