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. 2016 Sep 3;19(3):383–393. doi: 10.1093/neuonc/now175

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© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Fig. 1. — The angiogenic switch is linked to proneural-to-mesenchymal transition in GBM. (A) Highest differentially expressed genes between invasive (untr) and angiogenic (DN) tumors. (B) Biological processes linked to up- and downregulated genes. (C) Heatmap of Verhaak classification shows that invasive tumors (untr) have a proneural phenotype, while angiogenic (DN) tumors have a mesenchymal phenotype. (D) Transcription factor association to upregulated genes (DN). untr = untransduced EGFR amplified cells.