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. Author manuscript; available in PMC: 2017 Jun 8.
Published in final edited form as: Allergo J Int. 2015 Dec;24(8):303–311. doi: 10.1007/s40629-015-0085-x

Figure 1.

Figure 1

Mechanisms of action of acid suppression medication. While antacids and sucralfate directly bind protons in the gastric lumen, other drugs interfere with the gastric acid production of parietal cells. H2 receptor antagonists block the activating function of histamine via its H2 receptor. PPIs irreversibly inhibit the proton pump in the secretory cell membrane of parietal cells. The resulting elevated gastric pH leads to reduced pepsin activation in the stomach as well as duodenal secretin release, which substantially interferes with the gastrointestinal protein digestion.