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. 2017 Jan 4;19(5):648–659. doi: 10.1093/neuonc/now251

Fig. 1.

Fig. 1

CECR1 is highly expressed by M2-like macrophage in GBM. (A) Immunohistochemistry for CECR1, CD204, and CD206 in autopsy brain, astrocytoma grade II (AII), and grade IV (GBM) (scale bar: 200 µm). (B) Box plots displaying the mean percentages of CECR1, CD204, CD206-positive areas per image view in autopsy brains, AII, and GBM. *P < .05, ***P < .005. (C) Heat map summarizing the Spearman correlation coefficients between CECR1 and CD68, IL-12p35, iNOS, CD86, CD206, CD16, CD204, IL-10 in autopsy, astrocytoma grades II and III, and GBM. *P < .05, **P < .01. (D) Confocal images showing the colocalization of CECR1 with CD68 and Iba-1 in GBM (scale bar: 20 µm). (E) (F) Confocal images showing the colocalization of CECR1 with CD204 and CD163 in GBM (scale bar: 50 µm for the low magnification field; 10 µm for high magnification inlet).