Table 2. Mediation effects (Class 1).

Mediating Biomarkers	Adjusted Path a (Fig 1)	Z (p)	Effect (%)
alpha1-antitrypsin (A1AT)*[44–45], ![18]	-0.14, p < 0.001	2.93 (0.002)	24.0
FAS![17–18]	-0.09, p < 0.001	-3.14 (<0.001)	20.1
Heparin-binding EGF-like growth factor (HB-EGF)![18]	-0.13, p < 0.001	3.16 (<0.001)	23.2
Insulin-like Growth Factor-1 (IGF-I)![17–18]	-0.09, p < 0.001	-5.78 (<0.001)	14.0
Luteinizing Hormone (LH)![18]	-0.08, p < 0.001	-5.16(<0.001)	18.7
Macrophage Inflammatory Protein type 1 alpha (MIP-1a)![18]	-0.13, p < 0.001	3.06 (0.001)	13.8
Resitin*[44–15], ![17–18]	-0.07, p < 0.001	-4.54 (<0.001)	33.2
S100b*[46], ![17–18]	-0.13, p < 0.001	3.38 (<0.001)	18.3
Tissue Inhibitor of Metalloproteinase type 1 (TIMP-1)![18]	-0.13, p < 0.001	3.23 (<0.001)	20.4
Vascular Cell Adhesion Molecule type 1 (VCAM-1)![18]	-0.12, p < 0.001	2.53 (0.006)	9.6

*Previously recognized depression-specific serum protein biomarker

^!Previously recognized GDS adjusted biomarkers