Table 1. Feature grid of tools for human genome annotation and analysis.

This table shows the comparison of multiple tools and platforms that can be used for doing variant annotation, prioritization and clinical genome analysis.

Features	Mendel,MD	GEMINI	Ingenuity Variant Analysis	VarSeq	Sequence Miner	seqr	VCFMiner	BiERapp	Browse-VCF
Open Source	✓	✓	✘	✘	✘	✓	✓	✓	✓
Easy to use	✓	✘	✓	✓	✘	Not public	✘	✘	✘
Web Interface	✓	Partially	✓	✓	✓	Not public	✓	✓	✓
Public Server Available	✓	✘	✘	✘	✘	✘	✘	✓	✘
Example Datasets with Mendelian Disorders	✓	✘	✘	✘	✘	Not public	✘	✘	✘
Multi Sample Comparison	✓	✓	✓	✓	✓	✓	✓	✓	✓
Annotation	✓	✓	✓	✓	✓	✓	✓	✓	✓
Filtering	✓	✓	✓	✓	✓	✓	✓	✓	✓