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. 2017 Jun 8;12(6):e0177533. doi: 10.1371/journal.pone.0177533

Fig 3. Histological analysis of leucocyte infiltration, granulation tissue and collagen fibers of skin wounds 16 days after treatment with allo-mBM-MSCs and allo-acd-mMSCs in NOD mice.

Fig 3

Frequency of animals with the histological scores for: (A) leukocyte infiltration in the dermis, (B) granulation tissue formation stage and (C) quantitative analysis of the intensity of dermal collagen fibers. (n = 25, 25 and 27 for vehicle, allo-mBM-MSCs and allo-acd-mMSCs groups, respectively). Pearson’s chi-square test and variance (ANOVA) analysis were used, * indicates a significant difference p < 0.0001 and ** p < 0.05. Abbreviations: NOD, Non-Obese Diabetic; allo-mBM-MSCs, mouse bone marrow-derived allogeneic MSCs and allo-acd-mMSCs, mouse bone marrow acelullar derivatives allogeneic MSCs.