Table 4. Semi-quantitative analysis of tau pathology in individual autopsies.
| Tau pathology | Frontal cortex | Temporal cortex | Occipital cortex | Striatum | Globus pallidus | Thalamus | Nucleus basalis of Meynert | Amygdala | Entorhinal cortex | Substantia nigra | Locus coeruleus | Olfactory bulb | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FTLD-TDP type A (57 years, GRN+/p.A152T-) | NTs | ++ | + | + | + | - | - | + | + | + | + | - | + |
| PTs | + | + | - | - | - | + | + | + | + | - | - | + | |
| NFTs | + | - | - | - | - | - | - | + | - | - | - | - | |
| NPs | - | - | - | - | - | - | - | - | - | - | - | - | |
| ASTs | - | - | - | - | - | - | - | - | - | - | - | - | |
| FTLD-TDP type A (64 years, GRN+/p.A152T+) | NTs | + | + | + | + | - | - | + | + | + | + | + | + |
| PTs | + | + | - | - | - | - | - | + | ++ | - | - | - | |
| NFTs | - | - | - | - | - | - | - | - | - | - | - | - | |
| NPs | - | - | - | - | - | - | - | - | - | - | - | - | |
| ASTs | - | - | - | - | - | - | - | - | - | - | - | - | |
| FTLD-TDP type A(70 years, GRN+/p.A152T+) | NTs | - | + | - | - | + | - | + | + | + | + | + | - |
| PTs | - | - | - | - | + | - | - | + | + | - | + | - | |
| NFTs | - | - | - | - | - | - | - | + | - | + | - | - | |
| NPs | - | - | - | - | - | - | - | - | - | - | - | - | |
| ASTs | - | - | - | - | - | - | - | - | - | - | - | - | |
| FTLD-TDP type A (76 years, GRN+/p.A152T+) | NTs | - | + | - | - | - | - | + | + | + | - | - | - |
| PTs | - | + | - | - | - | - | + | + | + | - | - | - | |
| NFTs | - | + | - | - | - | - | + | + | - | - | - | - | |
| NPs | - | - | - | - | - | - | - | - | - | - | - | - | |
| ASTs | - | - | - | - | - | - | - | - | - | - | - | - | |
| FTLD-TDP type A + unclassifiable tauopathy(75 years, GRN+/p.A152T+) | NTs | + | +++ | + | + | ++ | + | +++ | +++ | +++ | ++ | ++ | + |
| PTs | + | +++ | - | ++ | ++ | - | +++ | +++ | +++ | - | ++ | + | |
| NFTs | - | +++ | + | ++ | + | + | + | ++ | + | ++ | + | - | |
| NPs | - | - | - | - | - | - | - | - | - | - | - | - | |
| ASTs | + | ++ | + | + | - | - | - | ++ | + | - | - | - | |
| FTLD-TDP type A + Alzheimer’s disease(71 years, GRN+/p.A152T+)) | NTs | + | ++ | - | + | - | - | + | - | + | + | ++ | - |
| PTs | - | + | - | + | - | + | + | ++ | + | - | +++ | - | |
| NFTs | - | + | - | - | - | - | - | + | - | - | + | - | |
| NPs | - | + | - | - | - | - | - | - | - | - | - | - | |
| ASTs | - | - | - | - | - | - | - | - | - | - | - | - | |
| FTLD-TDP type A + Alzheimer’s disease(76 years, GRN+/p.A152T+) | NTs | + | +++ | + | + | + | + | + | +++ | +++ | + | ++ | + |
| PTS | + | - | + | + | - | - | + | + | + | + | + | + | |
| NFTs | + | ++ | - | - | - | + | ++ | ++ | +++ | - | + | - | |
| NPSs | - | + | - | - | - | - | - | +++ | +++ | - | - | - | |
| ASTs | - | - | - | - | - | - | - | - | - | - | - | - |
ASTs: tau-positive astrocytic inclusions; NFTs: neurofibrillary tangles; NPs: neuritic plaques; NTs: neuropil threads; PTs: pretangles. -: no inclusions; +: mild density (isolated tau inclusions, barely noted at low magnification (x100); ++: moderate density (moderate tau inclusions, easily visible at low magnification (x100); +++: high density (abundant tau inclusions).