Fig 7. TNFα and IL-10 production by THP-1 macrophages stimulated with 2 mg/ml intact whey protein or whey hydrolysate in the presence or absence of celastrol.

Celastrol significantly inhibited both TNFα and IL-10 induced by intact whey protein and whey hydrolysates, demonstrating NF-κB dependency of the cytokine production. Significant differences were determined by using paired T tests. Significant differences were indicated by *.