Table 3. The association between methylation of BRCA2 gene and lifestyle factors among nurses and midwives in the cross-sectional study.
| Basic model ORa, 95%CI | Model 1 OR, 95%CI | |
|---|---|---|
| System of work | ||
| Day work (reference) | 1.00 | 1.00 |
| Rotating nights | 1.02 (0.69–1.51) | 1.09 (0.72–1.65)b |
| Duration of the night work in years | ||
| ≤10 (reference) | 1.00 | 1.00 |
| >10-≤20 | 0.91 (0.53–1.56) | 0.94 (0.55–1.63)b |
| >20 | 0.97 (0.61–1.54) | 1.02 (0.64–1.64)b |
| p-trend | 0.985 | 0.778 |
| Smoking status | ||
| Never (reference) | 1.00 | 1.00 |
| Former | 1.10 (0.68–1.77) | 1.09 (0.97–1.77)c |
| Current | 1.12 (0.71–1.76) | 1.11 (0.70–1.77) c |
| Amount of smoked cigarettes per day currently | ||
| Current non smoker(reference) | 1.00 | 1.00 |
| 1–4 | 1.19 (0.47–3.02) | 1.20 (0.47–3.08) c |
| 5–14 | 1.30 (0.76–2.22) | 1.27 (0.74–2.84) c |
| ≥15 | 0.84 (0.45–1.56) | 1.05 (0.69–1.62) c |
| p-trend | 0.970 | 0.958 |
| Smoking duration (in years) | ||
| 0 (reference) | 1.00 | 1.00 |
| ≤22.6 | 1.12 (0.66–1.89) | 1.09 (0.64–1.86) c |
| >22.6-≤31.0 | 0.88 (0.52–1.50) | 0.89 (0.52–1.51) c |
| >31.0 | 1.55 (0.89–2.73) | 1.55 (0.88–2.76) c |
| p-trend | 0.338 | 0.340 |
| Packyears | ||
| 0 (reference) | 1.00 | 1.00 |
| >0-≤10.4 | 1.30 (0.77–2.20) | 1.25 (0.73–2.14) c |
| >10.4-≤17.0 | 0.87 (0.49–1.54) | 0.85 (0.48–1.52) c |
| >17.0 | 1.20 (0.73–1.97) | 1.23 (0.73–2.02) c |
| p-trend | 0.607 | 0.544 |
| Alcohol drinking(no of drinks/wk) | ||
| 0-(reference) | 1.00 | 1.00 |
| >0–0.25 | 1.41 (0.52–3.81) | 1.38 (0.51–3.77) d |
| >0.25 –≤ 1 | 1.42 (0.52–3.90) | 1.37 (0.50–3.80) d |
| >1 | 1.52 (0.52–4.47) | 1.49 (0.50–4.42) d |
| p-trend | 0.287 | 0.279 |
| Lifelong duration of alcohol drinking (in years) | ||
| -20 (reference) | 1.00 | 1.00 |
| >20-≤30 | 0.81 (0.39–1.70) | 0.85 (0.51–1.43) d |
| >30 | 0.93 (0.45–1.95) | 1.23 (0.78–1.94) d |
| p-trend | 0.807 | 0.926 |
| Drinksyears(drinks/wk*years) | ||
| 0–5 (reference) | 1.00 | 1.00 |
| >5-≤10 | 0.88 (0.53–1.46) | 0.78 (0.37–1.64) d |
| >10 | 1.27 (0.82–1.97) | 0.89 (0.42–1.89) d |
| p-trend | 0.153 | 0.173 |
| Current alcohol abstinence | ||
| yes(reference) | 1.00 | 1.00 |
| no | 1.43 (0.54–3.80) | 1.39 (0.52–3.73) d |
| BMI(kg/m2) | ||
| <25 (reference) | 1.00 | 1.00 |
| ≤25 - <30 | 0.89 (0.57–1.37) | 0.86 (0.55–1.34)e |
| ≥30 | 0.79 (0.46–1.32) | 0.77 (0.46–1.30) e |
| p-trend | 0.089 | 0.096 |
| WHR | ||
| ≤0.85 (reference) | 1.00 | 1.00 |
| >0.85 | 0.87 (0.53–1.37) | 0.89 (0.56–1.42) e |
| p-trend | 0.993 | 0.942 |
| WHtR | ||
| ≤0.6 (reference) | 1.00 | 1.00 |
| >0.6 | 0.68 (0.40–1.12) | 0.70 (0.42–1.16) e |
| p-trend | 0.510 | 0.512 |
| Total physical activity (MET*hrs/wk) | ||
| ≤155 (reference) | 1.00 | 1.00 |
| >155- ≤220 | 0.92 (0.55–1.56) | 0.89 (0.52–1.53)f |
| >220 | 0.87 (0.53–1.45) | 0.84 (0.50–1.43)f |
| p-trend | 0.451 | 0.542 |
| Recreational PA | ||
| None (reference) | 1.00 | 1.00 |
| Any | 0.93 (0.61–1.43) | 0.89 (0.58–1.36)f |
a—adjusted for age and folate intake
b—adjusted for age, folate intake, current smoking, drinks per week, BMI and total PA
c–adjusted age, folate intake, drinks per week, BMI and total PA
d–adjusted for age, folate intake, current smoking, BMI and total PA
e–adjusted for age, folate intake, current smoking, drinks per week and total PA
f–adjusted for age, folate intake, current smoking, drinks per week and BMI