Table 2. SNPs allele distribution in HIV positive patients, HIV positive patients with fatty liver, healthy controls and alcoholic fatty liver.
| Healthy controls (n = 149) | HIV patients (all) (n = 117) | HIV patients with fatty liver (n = 13) | HIV patients with probable fatty liver (n = 65) | HIV patients without fatty liver (n = 39) | Patients with alcoholic fatty liver (n = 133) | |
|---|---|---|---|---|---|---|
| PNPLA3 (rs738409) | ||||||
| CC | 89 (59.7%) | 75 (64.1%) | 10 (76.9%) | 38 (58.5%) | 27 (69.2%) | 52 (39.1%) |
| GC | 53 (35.6%) | 37 (31.6%) | 2 (15.4%) | 25 (38.5%) | 10 (25.6%) | 64 (48.1%) |
| GG | 7 (4.7%) | 5 (4.3%) | 1 (7.7%) | 2 (3.1%) | 2 (5.1%) | 17 (12.8%) A) |
| CSPG3/NCAN (rs2228603) | ||||||
| CC | 124 (83.2%) | 104 (88.9%) | 11 (84.6%) | 57 (87.7%) | 36 (92.3%) | 107 (80.4%) |
| CT | 23 (15.4%) | 12 (10.3%) | 2 (15.4%) | 8 (12.3%) | 2 (5.1%) | 23 (17.3%) |
| TT | 2 (1.3%) | 1 (0.9%) | 0 (0%) | 0 (0%) | 1 (2.6%) | 3 (2.3%) |
| GCKR (rs780094) | ||||||
| GG | 53 (35.6%) | 41 (35.0%) | 3 (23.1%) | 18 (27.7%) | 20 (51.3%) | 49 (36.8%) |
| GA | 77 (51.7%) | 60 (51.3%) | 10 (76.9%) | 34 (52.3%) | 16 (41.0%) | 64 (48.1%) |
| AA | 19 (12.8%) | 16 (13.7%) | 0 (0%) | 13 (20.0%) | 3 (7.7%) | 20 (15.0%) |
| PPP1R3B (rs4240624) | ||||||
| AA | 124 (83.2%) | 96 (82.1%) | 12 (92.3%) | 50 (76.9%) | 34 (87.2%) | 112 (84.2%) |
| AG | 25 (16.8%) | 21 (17.9%) | 1 (7.7%) | 15 (23.1%) | 5 (12.8%) | 20 (15.0%) |
| GG | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (0.8%) |
| LYPLAL (rs12137855) | ||||||
| CC | 107 (71.8%) | 72 (61.5%) | 8 (61.5%) | 39 (60.0%) | 25 (64.1%) | 90 (67.7%) |
| CT | 38 (25.5%) | 40 (34.2%) | 5 (38.5%) | 22 (33.8%) | 13 (33.3%) | 40 (30.1%) |
| TT | 4 (2.7%) | 5 (4.3%) | 0 (0%) | 4 (6.2%) | 1 (2.6%) | 3 (2.3%) |
| TM6FS2 (rs8542926) | ||||||
| CC | 125 (83.9%) | 103 (88.0%) | 11 (84.6%) | 56 (86.2%) | 36 (92.3%) | 105 (78.9%) |
| CT | 22 (14.8%) | 13 (11.1%) | 2 (15.4%) | 9 (13.8%) | 2 (5.1%) | 23 (17.3%) |
| TT | 2 (1.3%) | 1 (0.9%) | 0 (0%) | 0 (0%) | 1 (2.6%) | 5 (3.8%) |
| MBOAT (rs626283) | ||||||
| CC | nd | 38 (32.5%) | 3 (23.1%) | 19 (29.2%) | 16 (41.0%) | Nd |
| CT | nd | 57 (48.7%) | 6 (46.2%) | 35 (52.3%) | 17 (43.6%) | Nd |
| TT | nd | 22 (18.8%) | 4 (30.8%) | 12 (18.5%) | 6 (15.4%) | Nd |
A) Patients with alcoholic fatty liver vs. healthy controls p = 0.00018