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. 2017 Jun 8;12(6):e0179174. doi: 10.1371/journal.pone.0179174

Fig 7. Effects of braylin on complete Freund’s adjuvant (CFA)-induced paw inflammation.

Fig 7

Mice were injected with braylin (BRA; 12.5–100 mg/kg), vehicle (50% propylene glycol in saline; control group) or dexamethasone (Dexa; 2 mg/kg; reference drug) by ip route 40 minutes before CFA (injected at time zero). (A) Inflammatory hyperalgesia measured at 2, 4, 8 and 24 hours after the CFA stimulus. The mechanical nociceptive threshold (axis of ordinates) is represented as the filament weight (g) in which the animal responds in 50% of presentations. (B) Paw edema measured at 2, 4, 8 and 24 hours after CFA, represented as paw volume variation. Data are expressed as means ± SEM; n = 6 mice per group. * Significantly different from the control group (p < 0.05). Two-way ANOVA followed by the Bonferroni’s test.