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. 2017 Jun 8;12(6):e0179265. doi: 10.1371/journal.pone.0179265

Table 1. Molecular signatures that demonstrate the greatest MI ratio.

Molecular Signatures MI Ratio MSDB Description
REACTOME_SOS_MEDIATED_SIGNALING 12.726 Genes involved in SOS-mediated signaling
BIOCARTA_CERAMIDE_PATHWAY 9.050 Ceramide signaling pathway
REACTOME_NOTCH_HLH_TRANSCRIPTION PATHWAY 8.565 Genes involved in Notch-HLH transcription pathway
MOOTH_FFA_OXYDATION 7.557 Genes involved in free fatty acid oxidation
REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 7.217 Genes involved in Processive synthesis on lagging strand
LANDIS_BREAST_CANCER_PROGRESSION_LP 7.141 Genes upregulated in preneoplastic mammary tissues
GOTZMANN_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 7.134 Genes upregulated during EMT
INGA_TP53_TARGETS 6.573 Genes with promotors containing TP53 response elements
NIKOLSKY_BREAST_CANCER_21Q22_AMPLICON 6.494 Genes within amplicon 21q22
REACTOME_POL_SWITCHING 6.490 Genes involved in polymerase switching
CROMER_METASTASIS_DN 6.381 Metastatic markers of head and neck cancers
SA_PROGRAMMED_CELL_DEATH 6.331 Genes involved in apoptosis
BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_DN 6.153 Genes down-regulated in ALI
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 6.134 Genes involved in SNARE interactions
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 5.964 Genes down-regulared in normal kidneys
MOSERLE_IFNA_RESPONSE 5.842 Upregulated genes in ovarian progenitor cells in response to IFN-α
HUANG_DASATINIB_RESISTANCE_UP 5.836 Genes with expression that correlates with dasatinib treatment
KEGG_BASE_EXCISION_REPAIR 5.835 Genes involved in base excision repair
PID_CERAMIDE_PATHWAY 5.824 Genes in the ceramide signaling pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 5.817 Genes down-regulated in response to LPA