Figure 1.
Losartan (L) normalized vasodilatory function, but not neurovascular coupling, in A/T mice. (a) The impaired cerebrovascular dilatations to ACh and CGRP in A/T mice (▾) were normalized by L (▿), but this was not accompanied by a recovery of baseline NO availability during NOS inhibition (L-NNA, 10−5 M). Dilatations induced by the NO donor SNP and contractile response to ET-1 remained unaltered in both treated- and untreated-A/T mice. Error bars represent SEM. n = 4 for each group. *p < 0.05, **p < 0.01, ***p < 0.001 when compared to WT, and ★p < 0.05, ★★p < 0.01, ★★★p < 0.001 when compared to treated-A/T mice using repeated measures ANOVA with genotype and treatment as the two variables, followed by Newman–Keuls post hoc test. (b) The impaired hyperemic response to whisker stimulation in A/T mice was not restored by L and remained reduced compared to the WT controls, as measured by LDF (n = 4 mice/group). Values represent the percent increase of CBF response relative to baseline. Error bars represent SEM. *p < 0.05 using two-way ANOVA followed by Newman–Keuls post hoc test.