Figure 5.

Losartan (L) on spatial learning and memory in A/T mice. (a) Visible platform session (days 1–3) demonstrated slightly albeit significantly longer latency only on day 3 in A/T mice compared to WT controls. A/T mice (▾) displayed impaired learning during hidden platform testing compared to aged-matched wild-type (WT) littermates (•). L did not improve the learning deficit in A/T-treated mice (▿) nor change that of the WT-treated mice (○). (b) L did not exert any effect on spatial memory relative to the untreated A/T mice as evidenced by the percent time spent and distance travelled in the target quadrant, as well as fewer crossings over the previously located platform during the probe trial. Error bars represent SEM (n = 8–12 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001 using repeated measures ANOVA with genotype and treatment as the two variables, followed by Newman–Keuls post hoc test.