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. 2016 Jan 1;37(6):1982–1993. doi: 10.1177/0271678X16658491

Figure 6.

Figure 6.

Acute hyperglycemia aggravates brain acidosis in ipsilateral hemisphere and augments infarct volume, which is attenuated in PARP1–/– mice. (a) Changes of brain pH in ipsilateral hemisphere at 45 min middle cerebral artery occlusion (MCAO). Mice were infused with saline or dextrose for 30 min before and 45 min during MCAO. Values are means ± 95% confidence intervals of the mean values for three to four animals per groups. * P < 0.05 from sham-operated animals; # P < 0.05 from MCAO animals infused with saline. (b) 3,5-Triphenyltetrazolium chloride (TTC) staining of coronal brain sections (1 mm thickness) three days after MCAO in representative wild-type (WT) mice that received an infusion of saline (WT saline) or dextrose (WT Dextrose). (c) Comparison of infarct volume in WT mice that received an infusion of saline (n = 12) or dextrose (n = 12). * P < 0.001 from WT saline. (d) Comparison of infarct volume between WT (n = 12) and PARP1–/– (n = 12) mice that received dextrose infusion. * P < 0.05 from WT dextrose.