. 2016 Jan 1;37(6):2137–2148. doi: 10.1177/0271678X16661339

Table 1.

Regional [¹¹C]Ro15-4513 parameters derived from 2TCM and competition binding analysis.

	Model selection			2TCM
ROI	AIC			V_T baseline	K₁ baseline (ml·min⁻¹·cm⁻³)	K₁ drug (ml·min⁻¹·cm⁻³)	$V_{α 5}$ (ml·cm⁻³)	$V_{α x}$ ^a (ml·cm⁻³)	$\frac{V_{S}}{V_{T}}$	$\frac{V_{α 5}}{V_{α 5} + V_{α x}}$
	1TCM	2TCM	Diff	Mean [±95% CI]	Mean [±95% CI]	Mean [±95% CI]	Mean [±95% CI]	Mean [±95% CI]
Insular ctx	−141.5	−169.2	27.6	8.97 [7.16, 10.78]	0.42 [0.39, 0.45]	0.42 [0.39, 0.45]	4.86 [4.29, 5.44]	2.05 [1.61, 2.49]	0.77	0.70
Anterior cingulate	−147.0	−171.7	24.7	7.16 [6.75, 7.57]	0.4 [0.37, 0.43]	0.4 [0.38, 0.42]	4.38 [3.81, 4.95]	1.92 [1.49, 2.35]	0.51	0.70
Cingulate ctx	−147.2	−167.7	20.4	6.46 [6.07, 6.85]	0.39 [0.36, 0.42]	0.41 [0.38, 0.44]	3.75 [3.19, 4.31]	1.88 [1.47, [2.30]	0.87	0.67
Occipital lobe	−171.3	−181.1	9.7	4.37 [4.17, 4.57]	0.4 [0.37, 0.43]	0.41 [0.38, 0.44]	1.67 [1.17, 2.18]	1.87 [1.48, 2.25]	0.81	0.47
Temporal lobe	−154.2	−182.7	28.5	5.70 [5.38, 6.02]	0.32 [0.30, 0.34]	0.33 [0.31, 0.35]	3.12 [2.56, 3.67]	1.73 [1.33, 2.14]	0.85	0.64
Parietal lobe	−168.7	−180.3	11.5	4.51 [4.27, 4.75]	0.4 [0.37, 0.43]	0.4 [0.37, 0.43]	2.03 [1.52, 2.54]	1.65 [1.26, 2.03]	0.82	0.55
Frontal lobe	−163.1	−183.4	20.3	4.85 [4.58, 5,12]	0.37 [0.34, 0.40]	0.38 [0.35, 0.41]	2.55 [2.01, 3.10]	1.49 [1.07, 1.91]	0.83	0.63
Parahippocampal gyrus	−149.6	−170.7	21.0	7.08 [5.80, 8.36]	0.26 [0.24, 0.28]	0.27 [0.26, 0.28]	3.92 [3.37, 4.48]	1.57 [1.15, 1.98]	0.78	0.71
Cerebellum	−181.5	−179.0	−2.4	2.29 [2.15, 2.43]	0.39 [0.36, 0.42]	0.42 [0.39, 0.45]	0.15 [−0.37, 0.67]	1.36 [0.98, 1.74]	0.66	0.10
Accumbens	−127.5	−165.1	37.6	11.05 [8.24, 13.86]	0.42 [0.39, 0.45]	0.41 [0.39, 0.43]	6.58 [5.96, 7.21]	1.63 [1.15, 2.11]	0.74	0.80
Hippocampus	−137.7	−177.7	40.0	8.13 [6.46, 9.80]	0.31 [0.30, 0.32]	0.32 [0.30, 0.34]	4.85 [4.29, 5.40]	1.49 [1.05, 1.93]	0.78	0.76
Amygdala	−138.7	−170.0	31.3	7.23 [6.45, 8.01]	0.3 [0.28, 0.32]	0.29 [0.27, 0.31]	5.12 [4.55, 5.69]	1.18 [0.72, 1.65]	0.87	0.81
Caudate	−155.2	−175.7	20.5	3.47 [3.25, 3.69]	0.38 [0.35, 0.41]	0.37 [0.34, 0.40]	2.06 [1.51, 2.62]	0.63 [0.22, 1.04]	0.31	0.77
Putamen	−142.6	−174.1	31.5	4.75 [4.31, 5.19]	0.45 [0.42, 0.48]	0.45 [0.43, 0.47]	2.97 [2.44, 3.51]	0.85 [0.44, 1.25]	0.80	0.78
Thalamus	−172.0	−183.0	11.1	3.01 [2.76, 3.26]	0.37 [0.35, 0.39]	0.37 [0.35, 0.39]	1.52 [1.01, 2.03]	0.65 [0.27, 1.03]	0.72	0.70
Midbrain	−178.6	−180.3	1.6	1.63 [1.47, 1.79]	0.3 [0.28, 0.32]	0.32 [0.31, 0.33]	0.47 [−0.05, 0.99]	0.36 [−0.02, 0.74]	0.51	0.57
Medulla	−171.2	−168.8	−2.3	1.00 [0.92, 1.08]	0.19 [0.16, 0.22]	0.2 [0.18, 0.22]	0.11 [−0.42, 0.65]	0.07 [−0.33, 0.47]	0.18	0.61
Pons	−190.5	−188.6	−1.8	0.91 [0.83, 0.99]	0.24 [0.23, 0.25]	0.24 [0.22, 0.26]	0.11 [−0.40, 0.63]	0.01 [−0.38, 0.40]	0.13	0.92

AIC: Akaike Information Criteria for model selection (smaller number indicates preferred model); V_T: total distribution volume; K₁: Delivery; $V_{α 5}$ : $α 5$ specific binding; $V_{α x}$ : non-selective specific binding; $V_{S} = V_{α 5} + V_{α x}$ : total specific binding.

Under the assumption that $V_{ND}$ is accurate and invariant across regions, mean and CI were calculated equal to $V_{T} - V_{α 5} - 0.78$ .