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Representative radio-HPLC chromatograms obtained from the plasma and the brain after [11C]diphenhydramine injection in rats. Data are chromatograms obtained from the plasma and the brain at 15 and 60 min. Peaks corresponding to parent (unmetabolized) [11C]diphenhydramine (DPH) and radiometabolite(s) (Metab) are shown on each chromatogram. Cpm: counts per minute. (a) Plasma (15 min), (b) brain (15 min), (c) plasma (60 min), and (d) brain (60 min).
