Figure 3.

CDK5miR facilitates the learning of a new platform location without forgetting a prior one. (A) The platform was located in quadrant A during learning and quadrant B during reversal learning and it was never located in the quadrants B and D. (B) A representative depiction of the route traveled during the reversal learning test is shown, and the number of crossings over each quadrant during each trial in the reversal learning period was determined. The data are expressed as the group mean ± SEM *Significant differences: p < 0.05; n = 12–15 animals/group. CDK5, cyclin-dependent kinase 5; SCR, scrambled RNA sequence.