Table 1.

Theiler’s murine encephalomyelitis virus

Classification	Theilovirus, the genus Cardiovirus, family Picornaviridae, order Picornavirales
	Two subgroups: neurovirulent GDVII (GDVII, FA), demyelinating TO (BeAn, DA)
Genome (8.1 kb)	Positive-sense ssRNA with IRES and poly(A) One ORF encoding non-structural proteins and four capsid proteins VP1-4
Replication (8 h)	Receptor binding → uncoating → polyprotein translation and processing → virion assembly → release by cell lysis

GDVII, George’s disease 7; IRES, internal ribosome entry site; ORF, open reading frame; ssRNA, single-stranded RNA; TO, Theiler’s original.