TABLE 5.
Study Cohort | Overall | By BMI Category | ||
---|---|---|---|---|
<25 | 25–29.9 | ≥30 | ||
Duke Prostate Center | ||||
Reference Model2 AUC (95% CI) |
0.68 (0.64–0.72) |
0.69 (0.62–0.76) |
0.69 (0.63–0.75) |
0.69 (0.63–0.75) |
DRE Model3 AUC (95% CI) |
0.71 (0.67–0.75) |
0.71 (0.64–0.78) |
0.72 (0.66–0.78) |
0.73 (0.67–0.79) |
P4 | 0.008 | 0.201 | 0.144 | 0.032 |
Durham VA | ||||
Reference Model2 AUC (95% CI) |
0.66 (0.61–0.70) |
0.75 (0.68–0.83) |
0.64 (0.57–0.71) |
0.63 (0.56–0.70) |
DRE Model3 AUC (95% CI) |
0.71 (0.67–0.76) |
0.78 (0.70–0.85) |
0.70 (0.63–0.76) |
0.71 (0.65–0.78) |
P4 | <0.001 | 0.304 | 0.066 | 0.018 |
La Sapienza University | ||||
Reference Model2 AUC (95% CI) |
0.69 (0.65–0.73) |
0.69 (0.61–0.77) |
0.70 (0.64–0.76) |
0.67 (0.58–0.76) |
DRE Model3 AUC (95% CI) |
0.74 (0.69–0.78) |
0.71 (0.63–0.79) |
0.75 (0.69–0.80) |
0.77 (0.69–0.86) |
P4 | 0.004 | 0.457 | 0.020 | 0.008 |
COMBINED5 | ||||
Reference Model2 AUC (95% CI) |
0.67 (0.64–0.69) |
0.69 (0.65–0.74) |
0.67 (0.64–0.71) |
0.66 (0.62–0.70) |
DRE Model3 AUC (95% CI) |
0.70 (0.68–0.73) |
0.71 (0.66–0.75) |
0.71 (0.67–0.74) |
0.72 (0.68–0.76) |
P4 | <0.001 | 0.198 | 0.005 | <0.001 |
Abbreviations: CaP, prostate cancer; BMI=body-mass index; DRE, digital rectal exam; AUC=area under receiver-operating characteristics curve; CI=confidence interval.
In reference to men who either had Gleason Sum <7 tumors or a negative biopsy.
Overall model with BMI as continuous variable adjusted for log BMI, log PSA, age at biopsy, year of biopsy, and ethnicity. Models stratified by BMI category adjusted for log PSA, age at biopsy, year of biopsy, and ethnicity. All models constructed using multivariable logistic regression.
Adjusted for DRE results, in addition to covariates for Reference Models using multivariable logistic regression.
Test of equality for AUCs between Reference and DRE Models.
Combined analyses additionally adjusted for study center.