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. Author manuscript; available in PMC: 2017 Jun 8.
Published in final edited form as: Prostate Cancer Prostatic Dis. 2011 Jul 5;14(4):346–353. doi: 10.1038/pcan.2011.31

TABLE 5.

Predictive accuracies for Gleason Sum ≥7 CaP detection1 in regression models with/without DRE findings.

Study Cohort Overall By BMI Category
<25 25–29.9 ≥30
Duke Prostate Center
Reference Model2
 AUC (95% CI)

0.68 (0.64–0.72)

0.69 (0.62–0.76)

0.69 (0.63–0.75)

0.69 (0.63–0.75)
DRE Model3
 AUC (95% CI)

0.71 (0.67–0.75)

0.71 (0.64–0.78)

0.72 (0.66–0.78)

0.73 (0.67–0.79)
P4 0.008 0.201 0.144 0.032
Durham VA
Reference Model2
 AUC (95% CI)

0.66 (0.61–0.70)

0.75 (0.68–0.83)

0.64 (0.57–0.71)

0.63 (0.56–0.70)
DRE Model3
 AUC (95% CI)

0.71 (0.67–0.76)

0.78 (0.70–0.85)

0.70 (0.63–0.76)

0.71 (0.65–0.78)
P4 <0.001 0.304 0.066 0.018
La Sapienza University
Reference Model2
 AUC (95% CI)

0.69 (0.65–0.73)

0.69 (0.61–0.77)

0.70 (0.64–0.76)

0.67 (0.58–0.76)
DRE Model3
 AUC (95% CI)

0.74 (0.69–0.78)

0.71 (0.63–0.79)

0.75 (0.69–0.80)

0.77 (0.69–0.86)
P4 0.004 0.457 0.020 0.008
COMBINED5
Reference Model2
 AUC (95% CI)

0.67 (0.64–0.69)

0.69 (0.65–0.74)

0.67 (0.64–0.71)

0.66 (0.62–0.70)
DRE Model3
 AUC (95% CI)

0.70 (0.68–0.73)

0.71 (0.66–0.75)

0.71 (0.67–0.74)

0.72 (0.68–0.76)
P4 <0.001 0.198 0.005 <0.001

Abbreviations: CaP, prostate cancer; BMI=body-mass index; DRE, digital rectal exam; AUC=area under receiver-operating characteristics curve; CI=confidence interval.

1

In reference to men who either had Gleason Sum <7 tumors or a negative biopsy.

2

Overall model with BMI as continuous variable adjusted for log BMI, log PSA, age at biopsy, year of biopsy, and ethnicity. Models stratified by BMI category adjusted for log PSA, age at biopsy, year of biopsy, and ethnicity. All models constructed using multivariable logistic regression.

3

Adjusted for DRE results, in addition to covariates for Reference Models using multivariable logistic regression.

4

Test of equality for AUCs between Reference and DRE Models.

5

Combined analyses additionally adjusted for study center.