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. Author manuscript; available in PMC: 2017 Jun 8.
Published in final edited form as: Trends Cell Mol Biol. 2016;11:55–65.

Table 1.

Differences in vessel structure and function between control and NG2 null mice#.

Parameter Change (versus control mice)
Germline-NG2ko mice PC-NG2ko mice Mac-NG2ko mice
Vessel structure
 Pericyte coverage of endothelial cells 45% decrease 33% decrease 47% decrease
 Detached pericyte 200% increase Unchanged 181% increase
 Vessel diameter 20% decrease* Unchanged 53% decrease
 Basal lamina assembly 73% decrease 31% decrease 72% decrease
 N-cadherin (endothelial cell) N.D. Unchanged 74% decrease
 N-cadherin (pericyte) N.D. Unchanged 97% decrease
Vessel function
 Vessel patency 50% decrease 43% decrease 48% decrease
 Vessel leakiness 400% increase 270% increase 416% increase
 Intratumoral hypoxia 2000% increase 560% increase 1580% increase
*

Change in vessel diameter of spontaneous mammary tumors between control and global-NG2 ko mice [23].

#

Reproduced with permission from Yotsumoto, F., You, W. K., Cejudo-Martin, P., Kucharova, K., Sakimura, K. and Stallcup, W. B. 2015, Oncoimmunol., 4, e1001204.