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. 2017 May 12;3(6):e161. doi: 10.1097/TXD.0000000000000677

FIGURE 5.

FIGURE 5

Viral infection lacking kidney tropism does not recapitulate the PyV-associated allograft injury phenotype seen in MPyV infection. B6 mOVA donor kidneys were transplanted into B6 recipients with bilateral nephrectomy. Mice were preoperatively given OT-I cells and infected on day 1 posttransplantation. Mice were infected with either MHV-68 or MPyV on day 1 posttransplantation. MPyV data are from Figure 2 and are shown for comparison. A, Survival. (●) MHV-68 infection (n = 4), (▲) MPyV infection (n = 5). B, Serum creatinine at time of death or day 30. Dots represent individual mice. Dashed line indicates limit of detection. C, Representative histology at day 30. OT-I T cell transfer and MHV-68 infection result is subclinical damage with minimal infiltration (H&E staining; original magnification, ×400).