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. Author manuscript; available in PMC: 2017 Aug 17.
Published in final edited form as: Science. 2017 Jan 5;355(6326):748–752. doi: 10.1126/science.aai8792

Fig. 1.

Fig. 1

New adipocytes only regenerate around new hair follicles during wound healing. (A) Histological sections (left two panels) and whole-mount images (right three panels) of skin stained to detect follicular epithelium (blue) and adipocytes (orange) in K14-Cre;R26R mice at indicated postwounding days. New adipocytes (arrowheads) increase in number and size over several days. (B) Skin viewed from the undersurface. New adipocytes form and persist exclusively around regenerated hair follicles, which arise in the center of the wound. (C) Cultured dermal cells isolated from wounds with regenerated hair follicles differentiated into BODIPY-positive (green) adipocytes, whereas cultured dermal cells from wounds lacking follicles formed no adipocytes. Scale bars in (A) and (C), 20 mm; in (B), 1 mm.