Table 3. Predictive values of sMICA in predicting liver fibrosis for MICArs2596542 A allele carriers.
| Non-advanced fibrosis F0-2 (N = 73) n (%) | Advanced fibrosis F34 (N = 84) n (%) | P value | SEN | SPE | PPV | NPV | |
|---|---|---|---|---|---|---|---|
| % | % | % | % | ||||
| sMICA detectable | 27 (37.0) | 53 (63.1) | < 0.001 | 63 | 63 | 66 | 60 |
| sMICA > 50 pg/mL | 16 (21.9) | 41 (48.8) | < 0.001 | 49 | 78 | 72 | 57 |
| sMICA > 100 pg/mL | 11 (15.1) | 23 (27.4) | 0.06 | 27 | 85 | 68 | 50 |
| Non-significant fibrosis F01 (N = 45) n (%) | Significant fibrosis F2-4 (N = 112) n (%) | P value | SEN | SPE | PPV | NPV | |
|---|---|---|---|---|---|---|---|
| % | % | % | % | ||||
| sMICA detectable | 16 (35.6) | 64 (57.1) | 0.01 | 57 | 64 | 80 | 38 |
| sMICA > 50 pg/mL | 6 (13.3) | 51 (45.5) | < 0.001 | 46 | 87 | 90 | 39 |
| sMICA > 100 pg/mL | 5 (11.1) | 29 (25.9) | 0.04 | 26 | 89 | 85 | 33 |
| FIB4 > 3.25* | 9 (20.0) | 65 (58.0) | < 0.001 | 58 | 80 | 88 | 43 |
| APRI > 1.5* | 14 (31.1) | 70 (62.5) | < 0.001 | 63 | 69 | 83 | 43 |
| Non cirrhosis F0-3 (N = 95) n (%) | Cirrhosis F4 (N = 62) n (%) | P value | SEN | SPE | PPV | NPV | |
|---|---|---|---|---|---|---|---|
| % | % | % | % | ||||
| sMICA detectable | 42 (44.2) | 38 (61.3) | 0.04 | 61 | 56 | 48 | 69 |
| sMICA > 50 pg/mL | 28 (29.5) | 29 (46.8) | 0.03 | 47 | 71 | 51 | 67 |
| sMICA > 100 pg/mL | 17 (17.9) | 17 (27.4) | 0.16 | 27 | 82 | 50 | 63 |
| APRI > 2* | 34 (35.8) | 32 (51.6) | 0.05 | 52 | 64 | 49 | 67 |
Note: MICA:MHC class Ipolypeptide-related chain A.Detectable sMICA: > 5.18 pg/mL. APRI: the aspartate aminotransferase-to-platelet ratio index.FIB-4:fibrosis index based on four factors.* Cut-off values of FIB4 and APRI defined by WHO.