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. 2017 Mar 6;8(20):32683–32695. doi: 10.18632/oncotarget.15950

Figure 3. Effects of USP22 up- and down-regulation on CRC cells.

Figure 3

(A–D). Scratch and transwell assays showed that migration and invasion abilities were significantly increased in USP22-up-regulated cells compared with the control. (E, F). Up-regulation of USP22 resulted in increased levels of N-cadherin, vimentin and AP4 and decreased E-cadherin expression as assessed by RT-PCR and western blot (WB) analysis. (G, H) RT-PCR and WB analysis demonstrated that N-cadherin, vimentin and AP4 expression were decreased and E-cadherin expression was increased in SW480 cells in which USP22 was down-regulated. Significance level as indicated: *p < 0.05; **p < 0.01; ***p < 0.001.