Figure 5. Effect of Carbenoxolone in tumor resection model.

(A) C57BL/6 mice were inoculated s.c. with 1.5 × 10⁶ LLC cells. A week prior to injection of cells, treatment of CAR 50 mg/kg i.p. q.o.d. was administered. When tumors reached volume of ~1000 mm³ (day 10) tumors were resected surgically and mice were monitored for an additional 21 days to allow metastases to develop. Lung resected and pictures were taken. (B) Number of lesions found in lungs of untreated mice compared with that found in mice treated with Carbenoxolone, p = 0.002. (C) Weight of lungs of untreated mice compared with lungs of mice under Carbenoxolone treatment p ≤ 0.05. n = 7. *p ≤ 0.05, **p ≤ 0.01