Table 1. An overall summary of the different treatments and results of all in vivo models that were applied in our study on the effect of Carbenoxolone on lung metastasis.

Model	Relevant processes in cancer formation	Dosage	Duration	Results
Subcutaneous Lung Model	Proliferation	50 mg/kg every other day	17 days	No significant difference
Orthotropic Lung Model	Proliferation	10 mg/kg every day	17 days	No significant difference
Tail Vein Injection – Lung Tumor Cell colonization	Adhesion Anoikis Colonization	40 mg/kg every other day	25 days	Treated group presented significantly lower number of lesions on lungs (p = 0.006)
Tumor Resection Lung Metastasis Model	Adhesion Anoikis Colonization Intravasation Migration	50 mg/kg every other day	38 days	Treated group presented significantly lower number of lesions on lungs (p = 0.002)