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. 2017 Mar 23;8(20):33047–33063. doi: 10.18632/oncotarget.16523

Figure 8. Schematic representation the dual role of iNOS/NO in cell glycolysis.

Figure 8

Chronic inflammation stimulates mild iNOS expression to produce nitric oxide slightly above physiological condition, which contributes to glycolysis and cell proliferation through inducing the PKM2 nuclear translocation in EGFR/ERK2-dependent manner. Acute inflammation stimulates iNOS expression to produce excess nitric oxide, which inhibits the nuclear translocation of PKM2 resulting in the glycolysis inhibition and tumor death.