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. 2017 Mar 25;8(20):33144–33158. doi: 10.18632/oncotarget.16562

Figure 7. FSCN1 is a target of miR-145.

Figure 7

(A) qRT-PCR and western blot analysis of the expression level of FSCN1 in parental and docetaxel-resistant LAD cells. (B) Effect of dysregulated miR-145 expression on the level of FSCN1 was measured by qRT-PCR and western blot analysis. (C) Bioinformatics predicted miR-145 binding sites at FSCN1. Luciferase activity in SPC-A1/DTX cells co-transfected with miR-145 and luciferase reporters containing no insert, FSCN1, or mutant FSCN1. Data are presented as the relative ratio of firefly luciferase activity to Renilla luciferase activity. Error bars represent the mean ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01 vs. control group.