Figure 8. Hypoxia induces PI3K, p-PI3K, AKT, p-AKT and suppressed AEG-1 by HIF-1α.

In this work, SMCs were subjected to different conditions, including (A) (hypoxia, normoxia), (B) (hypoxia: Akt inhibition, hypoxia: DMSO; normoxia: Akt inhibition, normoxia: DMSO), and (C) (hypoxia: si-HIF-1α, hypoxia: si-control; normoxia: si-HIF-1α, normoxia: si-control). The relative expressions levels of various proteins in the different groups with western blotting.